WG2

Genetic and environmental factors to understand dysbiosis including their interaction (epigenetics).

Dysbiosis is considered an essential cause of GIT diseases and must be discussed as a function of genetics and husbandry factors. Therefore, in this WG, geneticists, microbiologists, physiologists, nutritionists and immunologists will work together to manage the following tasks:

  •  To establish a multidisciplinary network to disclose the basis of intestinal dysbiosis in pigs.
  •  To improve the knowledge on the genetic potential of the most important European pig breeds, to increase the resistance against pathogens, with special emphasis on the immune response and gut maturation (novel molecular markers).
  •  To share biological samples of different pig populations and database based on genetic information (Single Nucleotide Polymorphism – SNPs) and traits related with the gut microbiome, heats and rearing conditions.
  • To define the most important phenotypes related with the gut microbiota and the best ways to collect/register them.
  • To share data and samples to improve the effectiveness of the GWAS in this field.
  •  To exchange experience, knowledge, protocols and bioinformatics tools, especially within ESRs in an international forum.
  • To discuss on the environmental factors as causes of dysbiosis (mother imprinting, diet, housing, etc.) and their interaction with the physiological and genetic make-up of pigs’ (epigenetics) parameters.
  •  To create a database based upon published literature and farm conditions to analyze the main environmental factors that in the field conditions modulate the gut microbiota.
  •  To define a priority list of factors determining the occurrence of dysbiosis and consequently create a road map to increases the resistance of pigs against the GIT infections.